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Related Experiment Video

Updated: May 2, 2026

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

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Ex-vivo lung perfusion.

Dirk Van Raemdonck1,2, Arne Neyrinck2,3, Marcelo Cypel4,5

  • 1Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.

Transplant International : Official Journal of the European Society for Organ Transplantation
|March 18, 2014
PubMed
Summary
This summary is machine-generated.

Ex vivo lung perfusion (EVLP) is a promising technique that can increase transplantable lungs and improve patient outcomes. This review discusses EVLP

Keywords:
ex vivo lung perfusionlung assessmentlung conditioninglung preservationlung repairlung transplantation

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Area of Science:

  • Cardiovascular and Respiratory System Sciences
  • Surgical and Medical Procedures

Background:

  • Lung transplantation is limited by donor organ availability.
  • Ex vivo lung perfusion (EVLP) offers a potential solution to assess and recondition donor lungs.
  • Improving donor lung utilization is critical for better transplant outcomes.

Purpose of the Study:

  • To review the emerging technique of ex vivo lung perfusion (EVLP).
  • To discuss the clinical potential of EVLP in increasing transplantable lungs.
  • To evaluate the impact of EVLP on early and late post-transplant outcomes.

Main Methods:

  • Review of current literature on ex vivo lung perfusion.
  • Discussion of the rationale, experimental background, and techniques of EVLP.
  • Analysis of available devices and global clinical experience with EVLP.

Main Results:

  • EVLP is a promising technique with the potential to expand the donor lung pool.
  • Clinical experience worldwide indicates feasibility and potential benefits of EVLP.
  • Ongoing clinical trials are investigating the long-term efficacy of EVLP.

Conclusions:

  • Ex vivo lung perfusion is a viable method to assess and potentially improve donor lungs.
  • EVLP can increase the number of lungs available for transplantation.
  • This technique holds promise for enhancing both short-term and long-term outcomes after lung transplantation.