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Updated: May 2, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
[When senescence hits the immune system]
1Klinisk Immunologisk Afdeling 7631, Rigshospitalet, Blegdamsvej 9, 2100 København Ø. helle.bruunsgaard@rh.regionh.dk
Abstract:
Ageing is associated with a reshaping of the immune system characterised by decreased adaptive immunity and systemic low-grade inflammation. These changes are associated with mortality in elderly cohorts and not only important in the defence to infectious diseases but also associated with almost all age-associated chronic diseases such as atherosclerosis, type 2 diabetes and dementia as well as their related risk factors. This review discusses underlying molecular and cellular mechanisms and possible intervention strategy today and in the future.
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