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Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
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Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae

Published on: July 19, 2021

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Insight into Tor2, a budding yeast microdomain protein

Katelyn Bartlett1, Kyoungtae Kim1

  • 1Department of Biology, Missouri State University, Springfield, MO 65897, USA.

European Journal of Cell Biology
|March 18, 2014
PubMed

Insights

The Tor2 kinase and its complex (TORC2) regulate key yeast cell functions like growth and actin polymerization. Further research is needed to fully understand Tor2 signaling networks.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Eukaryotic plasma membranes are organized into distinct microdomains.
  • Budding yeast Saccharomyces cerevisiae exhibits three microdomains: MCC, MCP, and MCT.
  • The Tor2 kinase and its complex, TORC2, are crucial regulators of cellular processes.

Purpose of the Study:

  • To review current evidence on the function and significance of Tor2.
  • To explore the implications and potential explanations for observed Tor2 phenomena.
  • To highlight the incomplete understanding of Tor2 signaling networks.

Main Methods:

  • Literature review of compelling evidence.
  • Analysis of Tor2's role in cellular functions.
  • Discussion of physiological significance and signaling pathways.

Main Results:

  • Tor2 is a highly conserved kinase and the main organizer of TORC2.
  • Tor2 regulates cell growth, actin polymerization, endocytosis, and sphingolipid synthesis.
  • Significant advancements have been made, but Tor2 signaling remains incompletely understood.

Conclusions:

  • Tor2 plays a vital role in multiple cellular functions in Saccharomyces cerevisiae.
  • Further investigation into Tor2 signaling networks is warranted.
  • Understanding Tor2's physiological significance is key to advancing cell biology research.
Keywords:
Membrane organizationMicrodomainsTORC2Tor2

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