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Updated: May 2, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

803

Hemoglobin A1c predicts heart failure hospitalization independent of baseline cardiac function or B-type natriuretic

Ichiro Kishimoto1, Hisashi Makino1, Yoko Ohata1

  • 1Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.

Diabetes Research and Clinical Practice
|March 18, 2014
PubMed

Insights

In patients with type 2 diabetes, higher HbA1c levels predict heart failure (HF) hospitalizations. This risk remains significant even after accounting for other HF risk factors and cardiac abnormalities.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Diabetes mellitus is a significant risk factor for developing heart failure (HF).
  • Understanding predictors of HF in diabetic populations is crucial for preventative strategies.

Purpose of the Study:

  • To determine if baseline glycated hemoglobin (HbA1c) predicts heart failure incidence in type 2 diabetes patients.
  • To assess if this association is independent of other established HF risk factors and cardiac structural/functional abnormalities.

Main Methods:

  • Utilized multivariable Cox regression models in a cohort of 608 patients with type 2 diabetes.
  • Examined the association between baseline HbA1c levels and future HF hospitalizations over a median follow-up of 6 years.

Main Results:

  • A 1% increase in baseline HbA1c was associated with a 23% increased hazard ratio for HF hospitalization (HR 1.23, 95% CI 1.1-1.7).
  • This association remained significant after adjusting for age, sex, BMI, blood pressure, and B-type natriuretic peptide (BNP).
  • HbA1c's predictive effect was independent of left ventricular ejection fraction, diastolic function, and coronary heart disease status.

Conclusions:

  • Baseline HbA1c is a significant independent predictor of future heart failure hospitalizations in patients with type 2 diabetes.
  • HbA1c predicts HF risk beyond established markers like BNP and echocardiographic parameters.
Abstract

Keywords:
Glycated hemoglobinHeart failureType 2 diabetes

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