Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

1.5K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
1.5K
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

259
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
259
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

1.1K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.1K
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

116
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
116
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

398
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
398
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

308
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
308

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coverage and quality of patient participation groups: a mixed-methods analysis of Care Quality Commission reports.

The British journal of general practice : the journal of the Royal College of General Practitioners·2025
Same author

The impact of the COVID-19 pandemic on students' views of a career in general practice: a focus group study.

BJGP open·2024
Same author

Variations in achievement of evidence-based, high-impact quality indicators in general practice: An observational study.

PloS one·2017
Same author

Barriers to effective management of type 2 diabetes in primary care: qualitative systematic review.

The British journal of general practice : the journal of the Royal College of General Practitioners·2016
Same author

Developing 'high impact' guideline-based quality indicators for UK primary care: a multi-stage consensus process.

BMC family practice·2015
Same author

Being and becoming a clinician: ethnographic insights.

Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors·2015
Same journal

An integrated organisation-wide data quality management and information governance framework: theoretical underpinnings.

Informatics in primary care·2014
Same journal

Mapping French terms in a Belgian guideline on heart failure to international classifications and nomenclatures: the devil is in the detail.

Informatics in primary care·2014
Same journal

Advantages of using voiced questionnaire and image capture application for data collection from a minority group in rural areas along the Thailand-Myanmar border.

Informatics in primary care·2014
Same journal

Effectiveness of local support for the adoption of a national programme--a descriptive study.

Informatics in primary care·2014
Same journal

Using video-based observation research methods in primary care health encounters to evaluate complex interactions.

Informatics in primary care·2014
Same journal

The John Bryden memorial lecture: Improving health with the community health index and developments in record linkage.

Informatics in primary care·2014
See all related articles

Related Experiment Video

Updated: May 2, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K

General practitioners' views on using a prescribing substitution application (ScriptSwitch(®)).

Carly Hire1, Bruno Rushforth2

  • 1Academic Unit of Primary Care, Leeds Institute of Health Sciences, Faculty of Medicine and Health, University of Leeds, UK. um08ch@leeds.ac.uk.

Informatics in Primary Care
|March 18, 2014
PubMed
Summary
This summary is machine-generated.

General practitioners (GPs) found the ScriptSwitch application acceptable for cost-effective prescribing but perceived its impact as limited. Enhancing the tool with more GP control could improve its success in managing drug costs.

More Related Videos

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K
Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

11.8K

Related Experiment Videos

Last Updated: May 2, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K
Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

11.8K

Area of Science:

  • Health Services Research
  • General Practice
  • Pharmacoeconomics

Background:

  • General practitioners (GPs) face increasing pressure to prescribe cost-effectively due to rising expenditure and budget constraints.
  • A computerised prescribing substitution application, ScriptSwitch®, offers cost-saving drug switch suggestions at the point of prescription.
  • This application has been implemented by UK health commissioning organisations for medicines management.

Purpose of the Study:

  • To explore general practitioners' (GPs) perspectives on utilizing a prescribing substitution application in their daily clinical practice.
  • To understand the factors influencing GP engagement with computerised decision support for cost-effective prescribing.

Main Methods:

  • A qualitative study design was employed, utilizing face-to-face semi-structured interviews.
  • Eight general practitioners (GPs) from five practices in one North of England commissioning area participated.
  • Interview data were audio-recorded, transcribed verbatim, and subjected to thematic analysis.

Main Results:

  • Six key themes emerged: GP acceptance, application impact, external control, workflow disruption, GP willingness to switch, and patient willingness to switch.
  • GPs generally accepted the application for promoting cost-effective prescribing but noted its limited impact alongside existing initiatives.
  • A lack of application 'learning' and perceived tension between patient choice and prescribing priorities were significant findings.

Conclusions:

  • Clinician, patient, and organisational factors influence engagement with prescribing substitution tools.
  • While generally accepted, the application's effectiveness is constrained by its perceived limitations and the need to balance individual patient needs with population prescribing goals.
  • Customisation of the application to local prescribing priorities and increased GP control may improve its successful adoption and impact.