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Strategies for Assessing Autistic-Like Behaviors in Mice
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When and how does autism begin?

Jennifer M D Yoon1, Athena Vouloumanos1

  • 1Psychology Department, New York University, New York, NY, USA.

Trends in Cognitive Sciences
|March 18, 2014
PubMed
Summary

Early autism spectrum disorder (ASD) diagnosis may be possible. A decline in eye fixations between 2 and 6 months predicts ASD, representing the earliest known behavioral pattern.

Area of Science:

  • Developmental psychology
  • Neurodevelopmental disorders
  • Pediatric medicine

Background:

  • Autism spectrum disorder (ASD) is a neurodevelopmental condition.
  • Reduced eye fixation is a known characteristic in older children with ASD.
  • The developmental trajectory of eye fixation in infancy and its predictive value for ASD remain under investigation.

Purpose of the Study:

  • To investigate the developmental course of eye fixation in infants.
  • To determine if early changes in eye fixation predict later diagnosis of autism spectrum disorder (ASD).
  • To identify the earliest behavioral marker for ASD.

Main Methods:

  • Longitudinal study tracking infant eye movements.
  • Analysis of eye fixation patterns between 2 and 6 months of age.

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  • Correlation of early eye fixation decline with later ASD diagnosis.
  • Main Results:

    • Decreased eye fixations were not observed throughout infancy in children later diagnosed with ASD.
    • A significant decline in eye fixations between 2 and 6 months of age predicted ASD diagnosis.
    • This early decline represents the earliest identified behavioral pattern associated with ASD.

    Conclusions:

    • Infant eye fixation patterns change in the first six months of life.
    • A decline in eye fixation during this period is a potential early diagnostic indicator for autism spectrum disorder (ASD).
    • This finding offers a novel, early behavioral marker for ASD.