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Increased association between febrile convulsion and allergic rhinitis in children: a nationwide population-based

Wen-Ya Lin1, Chih-Hsin Muo2, Yi-Chia Ku1

  • 1Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.

Pediatric Neurology
|March 18, 2014
PubMed

Insights

Febrile convulsions in children may increase the risk of developing allergic rhinitis. Frequent medical visits for febrile convulsions are linked to a higher incidence of allergic rhinitis.

Area of Science:

  • Pediatrics
  • Immunology
  • Epidemiology

Background:

  • Febrile convulsions and allergic rhinitis are common childhood disorders.
  • While generally benign, allergic rhinitis can impact school performance and social interaction.
  • No prior studies have reported on the association between febrile convulsions and allergic rhinitis.

Purpose of the Study:

  • To investigate the potential association between febrile convulsions and the subsequent development of allergic rhinitis in children.
  • To analyze data from a Taiwanese nationwide cohort database to explore this relationship.

Main Methods:

  • A cohort of 1304 children with febrile convulsions was identified.
  • Controls were matched 1:4 based on age, sex, urbanization, and parental occupation.
  • Cox's proportional hazards regression model was employed to estimate the risk of allergic rhinitis.

Main Results:

  • The incidence of allergic rhinitis was higher in the febrile convulsions group (65.16 per 1000 person-years) compared to controls (51.45 per 1000 person-years).
  • Children with febrile convulsions had a 1.21 times higher risk of developing allergic rhinitis (95% CI, 1.08-1.36).
  • A significantly increased risk of allergic rhinitis was observed with more than three febrile convulsion-related medical visits (P < 0.0001).

Conclusions:

  • Febrile convulsions may be associated with an increased risk of allergic rhinitis in children.
  • A higher cumulative incidence of allergic rhinitis was noted in children with frequent febrile convulsion-related medical visits.
  • Further research is warranted to elucidate the potential link, given shared cytokine profiles and viral associations.
Abstract

Keywords:
allergic rhinitisatopyfebrile convulsioninterleukin-1b

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