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Flow Cytometric Analysis of Extracellular Vesicles from Cell-conditioned Media
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Fluid vesicles in flow.

David Abreu1, Michael Levant2, Victor Steinberg2

  • 1II. Institut für Theoretische Physik, Universität Stuttgart, 70550 Stuttgart, Germany.

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|March 18, 2014
PubMed
Summary
This summary is machine-generated.

Giant fluid vesicles exhibit complex dynamics in hydrodynamic flow, influenced by membrane elasticity and thermal fluctuations. New regimes like "trembling" emerge, impacting vesicle behavior and offering insights into biological fluid dynamics.

Keywords:
Bending energyMigrationRheologyThermal fluctuationsVesicleViscous flow

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Area of Science:

  • Soft matter physics
  • Fluid dynamics
  • Biophysics

Background:

  • Giant fluid vesicles are model systems for biological cells.
  • Their behavior in flow is critical for understanding biological processes like blood flow.
  • Existing models describe some flow regimes but not all complex dynamics.

Purpose of the Study:

  • To review the dynamical behavior of giant fluid vesicles in various hydrodynamic flows.
  • To elucidate the interplay between membrane elasticity, flow stresses, and thermal fluctuations.
  • To highlight emerging phenomena and their implications.

Main Methods:

  • Theoretical modeling
  • Numerical simulations
  • Review of experimental observations

Main Results:

  • Vesicles exhibit tank-treading, tumbling, and a novel "trembling" regime with asymmetric deformations.
  • Strong flows induce wrinkles, dumbbells, and pearling in vesicles.
  • Vesicle migration and deformation in capillary flows are influenced by wall forces and shear stress.

Conclusions:

  • Hydrodynamic flow induces rich and complex dynamics in giant fluid vesicles.
  • Understanding these dynamics is crucial for applications in biophysics and fluid mechanics.
  • Further research on vesicle suspensions can illuminate phenomena in biological systems like blood flow.