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Selective decrease of large neurons in the neostriatum in progressive supranuclear palsy.

K Oyanagi1, H Takahashi, K Wakabayashi

  • 1Department of Neuropathology, Niigata University, Japan.

Brain Research
|August 23, 1988
PubMed
Summary
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Progressive supranuclear palsy (PSP) significantly reduces large neurons in the neostriatum, specifically the caudate nucleus and putamen. Small neuron populations remain largely unaffected in PSP patients.

Area of Science:

  • Neuroscience
  • Neuropathology

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
  • Quantitative changes in the neostriatum are not well understood in PSP.

Purpose of the Study:

  • To evaluate quantitative neuronal changes in the neostriatum of PSP patients.
  • To compare these changes with controls and Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT).

Main Methods:

  • Klüver-Barrera staining of caudate nucleus (CN) and putamen (PT) sections from 4 PSP patients.
  • Neuron cell body and nuclear area measurement using a digitizer.
  • Comparison with previously reported data from 6 controls and 4 AD/SDAT subjects.

Main Results:

  • A significant reduction (40% in CN, 30% in PT) in large neurons (nuclear area > 101 μm²) in PSP compared to controls (P < 0.01).

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  • Small neurons (nuclear area < 100 μm²) were well preserved in PSP.
  • Neuronal changes in PSP were similar to those observed in AD/SDAT.

    • Conclusions:

    • PSP is characterized by a substantial loss of large neurons in the caudate nucleus and putamen.
    • The preservation of small neurons suggests a specific vulnerability of larger neuronal populations in PSP.
    • Findings contribute to understanding the neuropathological basis of PSP and its differentiation from other dementias.