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Updated: May 2, 2026

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
Published on: June 30, 2019
Overview and phylogeny of Mycobacterium tuberculosis complex organisms: implications for diagnostics and legislation
Sabrina Rodriguez-Campos1, Noel H Smith2, Maria B Boniotti3
1Institute of Veterinary Bacteriology, Veterinary Faculty, University of Bern, Laenggassstrasse 122, 3012 Bern, Switzerland.
Abstract:
Members of the Mycobacterium tuberculosis complex (MTBC) cause a serious disease with similar pathology, tuberculosis; in this review, bovine tuberculosis will be considered as disease caused by any member of the MTBC in bovids. Bovine tuberculosis is responsible for significant economic loss due to costly eradication programs and trade limitations and poses a threat to both endangered and protected species as well as to public health. We here give an overview on all members of the MTBC, focusing on their isolation from different animal hosts. We also review the recent advances made in elucidating the evolutionary and phylogenetic relationships of members of the MTBC. Because the nomenclature of the MTBC is controversial, its members have been considered species, subspecies or ecotypes, this review discusses the possible implications for diagnostics and the legal consequences of naming of new species.
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