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The electroretinogram in multiple sclerosis and demyelinating optic neuritis.

D Papakostopoulos1, F Fotiou, J C Hart

  • 1Burden Neurological Institute, Bristol, U.K.

Electroencephalography and Clinical Neurophysiology
|January 1, 1989
PubMed
Summary

Demyelinating optic neuritis causes early retinal damage, affecting the

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Clinical Electrophysiology

Background:

  • Multiple sclerosis (MS) can cause demyelinating optic neuritis (DON).
  • Retinal involvement in DON is not fully understood.
  • Neurophysiological assessment is crucial for understanding optic nerve damage.

Purpose of the Study:

  • To investigate retinal function in patients with demyelinating optic neuritis.
  • To differentiate between demyelination and retinal damage in DON.
  • To identify early electrophysiological markers of retinal pathology in DON.

Main Methods:

  • Recorded pattern reversal visual evoked potentials (PR-VEPs) and electroretinograms (ERGs) in patients with MS and DON, and controls.
  • Utilized flicker following ERG (FF-ERG) at 40 Hz.

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  • Employed skin electrodes and signal averaging techniques.

    • Main Results:

    • PR-VEPs were absent or delayed in affected eyes.
    • The 'b' wave amplitude of the ERG was reduced in affected eyes.
    • FF-ERG amplitude was diminished in affected eyes, suggesting retinal damage.

    Conclusions:

    • Retinal damage is an early feature of demyelinating optic neuritis.
    • This damage is not solely due to myelin loss but affects retinal elements.
    • Müller glial cells may be involved in the 'b' wave generation affected in DON.