Related Experiment Video
Updated: May 2, 2026
14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
17.8K
Ligand-mediated active targeting for enhanced oral absorption.
1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, Shanghai, China; School of Pharmacy, Jinan University, Guangzhou, China.
Drug Discovery Today
|March 18, 2014
Summary
Innovative ligand-mediated targeting strategies enhance oral drug delivery for poorly soluble or unstable therapeutics. This approach improves bioavailability and therapeutic efficacy for challenging medications.
Area of Science:
- Pharmacology
- Drug Delivery
- Biotechnology
Background:
- Oral drug administration is preferred for patient compliance but faces challenges with poorly soluble, permeable, or unstable drugs like proteins.
- Low oral bioavailability limits the therapeutic potential of many essential medications.
- Innovative delivery systems are crucial for overcoming these limitations.
Purpose of the Study:
- To review the current advancements in ligand-mediated targeting for oral drug delivery.
- To discuss strategies for improving the oral bioavailability of therapeutics with poor absorption.
- To highlight the potential of targeting intestinal epithelia for enhanced drug uptake.
Main Methods:
- Review of recent scientific literature on oral drug delivery systems.
- Analysis of ligand-decorated carriers and their mechanisms of action.
- Focus on ligand-mediated targeting to intestinal epithelial cells.
Main Results:
- Ligand-mediated targeting shows promise for enhancing oral absorption of poorly bioavailable drugs.
- Targeting strategies can improve drug localization and uptake in the intestinal epithelium.
- Novel delivery systems are crucial for overcoming oral absorption barriers.
Conclusions:
- Ligand-mediated targeting represents a significant advancement in oral drug delivery technology.
- Further research in this area can lead to improved therapeutic outcomes for challenging drugs.
- Targeting intestinal epithelia offers a viable route for enhancing oral bioavailability.
More Related Videos
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
352
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
352
01:24Modified-Release Drug Delivery Systems: Site-Targeted
164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
332
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
332
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
733
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
733
01:23Oral Drug Delivery Systems: Introduction
279
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
279