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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Gene variation in IL10 and susceptibility to chronic hepatitis B
Tian-Chen Zhang1, Wen-Feng Zhang2, Yu-Qin Zhao3
1Department of Communicable Diseases Control, Jiangxi Provincial Center for Disease Control and Prevention, 555 Beijing East Road, Nanchang 330000, Jiangxi, China.
Objectives:
To evaluate the correlation between IL-10 gene polymorphisms and hepatitis B infection.
Methods:
Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between IL-10 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls.
Results:
This study found that rs3024490 G/T allele, located in the intron 1 region and highly prevalent in Chinese populations, was significantly different between the chronic HBV infection cases and the acute infection controls in single allele analysis, genetic models analysis, and haplotypes analysis.
Conclusions:
This suggested that the rs3024490 within IL-10 was associated with susceptibility to chronic hepatitis B in a Chinese Han population.
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