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Regulatory constraints in the generation and differentiation of IgE-expressing B cells

Zhiyong Yang1, Marcus J Robinson1, Christopher D C Allen2

  • 1Cardiovascular Research Institute and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Current Opinion in Immunology
|March 18, 2014
PubMed

B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.

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