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Published on: March 23, 2018
Allergen-specific IgE antibody serologic assays in patients with autoimmune pancreatitis
Sawako Kuruma1, Terumi Kamisawa, Taku Tabata
1Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Objective:
To clarify the allergic manifestations in patients with autoimmune pancreatitis (AIP).
Methods:
We assessed 67 AIP patients, before they received steroid therapy, for a past history of allergic disease, the peripheral eosinophil count (n=62) and the serum IgE level (n=53). Allergen-specific IgE antibody serologic assays were performed in 15 patients.
Results:
A positive past history and/or the presence of active allergic disease were found in 24 AIP patients (36%), including 15 patients with acute allergic rhinitis and eight patients with bronchial asthma. Peripheral eosinophilia and elevation of the serum IgE level were detected in 16% (10/62) and 60% (32/53) of the patients, respectively. Allergen-specific IgE antibody serologic assays were positive in 13 patients (87%). There were no differences between the assay-positive and -negative patients regarding the clinical profiles.
Conclusion:
In conclusion, 87% of the 15 AIP patients tested had positive allergen-specific IgE antibody serologic assays. Allergic mechanisms may be related to the occurrence of AIP.
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