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Synovial sarcoma in children and adolescents
Anna Kerouanton1, Irene Jimenez, Cecile Cellier
1*Pediatric, Adolescent and Young Adult Department Departments of †Radiology ‡Medical Oncology #Pathology §Radiotherapy Department, Institut Curie ∥Pediatric Orthopedic Department, Necker Hospital-Assistance Publique, Université Paris Descartes-Sorbonne Paris ¶Pediatric Orthopedic Department, Armand Trousseau Hospital-Assistance Publique, Paris, France.
Journal of Pediatric Hematology/Oncology
|March 18, 2014
Summary
Synovial sarcoma (SS) is a rare soft tissue cancer. This study updates pediatric SS treatment, comparing outcomes to adult SS cases for better therapeutic strategies.
Area of Science:
- Oncology
- Pediatric Oncology
- Soft Tissue Sarcomas
Background:
- Synovial sarcoma (SS) is a high-grade soft tissue sarcoma known for local invasiveness and metastasis.
- It affects pediatric, adolescent, and adult populations, with peak incidence in the third decade.
- SS is the most common nonrhabdomyosarcoma soft tissue sarcoma in childhood and adolescence.
Purpose of the Study:
- To propose an update on synovial sarcoma (SS) management in the pediatric population.
- To analyze and compare treatment outcomes in pediatric SS patients with those in adult SS patients.
Main Methods:
- Review and analysis of treatment modalities and outcomes for pediatric SS.
- Comparative analysis of pediatric SS data against established adult SS treatment protocols and results.
Main Results:
- Pediatric and adult SS present similarly clinically and radiologically.
- Historically, pediatric SS was treated as chemosensitive (rhabdomyosarcoma philosophy), while adult SS is often considered poorly chemosensitive with a focus on local control.
- The study analyzes updated treatment approaches and outcomes for pediatric SS.
Conclusions:
- Treatment strategies for synovial sarcoma (SS) may need age-specific adjustments.
- Further research and updated guidelines are necessary for optimizing pediatric SS treatment.
- Comparative analysis provides insights into age-related differences in SS management and prognosis.
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