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Updated: May 2, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
Published on: August 16, 2012
Simulating the co-encapsulation of drugs in a "smart" core-shell-shell polymer nanoparticle
1Department of Science, Robert Morris University, 15108, Moon Township, USA, buxton@rmu.edu.
Abstract:
A coarse-grained lattice Monte Carlo method is used to simulate co-encapsulation and delivery of both a hydrophilic and hydrophobic drug from polymer nanoparticles. In particular, core-shell-shell polymer nanoparticles with acid-labile bonds are simulated, and the preferential release of the encapsulated drugs near more acidic tumors is captured. While these simple models lack the molecular details of a real system, they can reveal interesting insights concerning the effects of entropy and enthalpy in these systems.
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