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SETting OP449 into the PP2A-activating drug family

Paolo Neviani1, Danilo Perrotti

  • 1Authors' Affiliations: The Ohio State University Comprehensive Cancer Center, Columbus, Ohio; and Department of Medicine, The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|March 18, 2014
PubMed
Summary

Protein Phosphatase 2A (PP2A) is crucial for suppressing tumors but is inactivated in leukemia by inhibitors like SET. The drug OP449 activates PP2A by inhibiting SET, thus hindering leukemia development and supporting its use in patients.

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