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Tissue Engineering of a Human 3D in vitro Tumor Test System
Published on: August 6, 2013
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TISSUE ENGINEERING PERFUSABLE CANCER MODELS
E L Fong1, M Santoro2, M C Farach-Carson3
1Department of Bioengineering, Rice University, Houston, TX 77030.
Current Opinion in Chemical Engineering
|March 18, 2014
Summary
Understanding fluid flow
Area of Science:
- Oncology
- Biophysics
- Biomedical Engineering
Background:
- The impact of fluid flow on cancer progression remains poorly understood.
- There is a critical need for advanced tumor models to investigate these effects.
- Current models often lack the ability to fully replicate the tumor microenvironment's complexity.
Purpose of the Study:
- To highlight the necessity of perfused tumor models for studying cancer progression.
- To explore the utility of microfluidic and macroscale models in cancer research.
- To emphasize the importance of fluid dynamics in mimicking the tumor microenvironment.
Main Methods:
- Utilizing microfluidic tumor models for high spatiotemporal control of cellular processes.
- Investigating cell-cell interactions and tumor cell migration under interstitial flow.
- Employing macroscale models to capture the multi-scale nature of tumor growth and invasion.
Main Results:
- Microfluidic models enable detailed study of cellular behaviors influenced by flow.
- Macroscale models are essential for understanding broader cancer growth dynamics.
- Integrating micro- and macroscale fluid dynamics offers a more comprehensive approach.
Conclusions:
- Perfused tumor models are crucial for elucidating the role of fluid flow in cancer.
- A multi-scale modeling approach, incorporating both microfluidic and macroscale perspectives, is vital.
- Better understanding of fluid dynamics in tumors can significantly improve cancer progression modeling.
