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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment02:17

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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
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Tumor microenvironment and nanotherapeutics.

Meenakshi Upreti1, Amar Jyoti1, Pallavi Sethi1

  • 1Department of Pharmaceutical Sciences and Cancer Nanotechnology Training Center, College of Pharmacy, University of Kentucky, Lexington, KY, USA.

Translational Cancer Research
|March 18, 2014
PubMed
Summary
This summary is machine-generated.

Nanotechnology offers novel cancer therapies by targeting the tumor microenvironment. Smart nanoparticles enable early diagnosis and improved treatment through drug delivery and imaging, enhancing patient quality of life.

Keywords:
Tumor microenvironmentendothelial cellsenhanced permeability and retention (EPR) effectmultiple drug resistance (MDR)nanoparticles

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Area of Science:

  • Oncology
  • Nanotechnology
  • Cancer Biology

Background:

  • The tumor microenvironment plays a critical role in cancer growth and progression.
  • Understanding the tumor microenvironment's cellular and noncellular interactions is key for developing new cancer therapies.
  • Nanotechnology provides a platform for advanced cancer treatment strategies.

Purpose of the Study:

  • To review how nanotechnology exploits tumor microenvironment characteristics for novel drug delivery systems.
  • To highlight the development of "smart" nanoparticles for targeted cancer therapy and early diagnosis.
  • To discuss the potential of nanotechnology-based combinatorial treatments for improved therapeutic efficacy.

Main Methods:

  • Review of recent studies on tumor microenvironment and nanotherapies.
  • Analysis of nanoparticle design for targeted drug delivery and imaging.
  • Exploration of multimodality treatment strategies involving nanoparticles.

Main Results:

  • Multifunctional nanoparticles can carry imaging agents and multiple drugs for targeted delivery to the tumor microenvironment.
  • Nanoparticle-based combinatorial strategies, including chemotherapy, radiotherapy, and antiangiogenesis, show promise.
  • Targeted delivery enhances early diagnosis and treatment effectiveness.

Conclusions:

  • Exploiting tumor microenvironment features with nanotechnology enables the rational design of advanced cancer nanotherapies.
  • Smart nanoparticles offer a pathway to improved therapeutic efficacy and patient quality of life.
  • Multimodality nanoparticle-based treatments represent a significant advancement in oncology.