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CD84 is markedly up-regulated in Kawasaki disease arteriopathy

R Reindel1, J Bischof, K-Y A Kim

  • 1Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, USA.

Clinical and Experimental Immunology
|March 19, 2014
PubMed

Insights

Kawasaki disease (KD) causes persistent inflammation in coronary arteries (CA). Researchers found the CD84 molecule significantly increased in KD CA, indicating potential new therapeutic targets for this childhood illness.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Molecular Biology

Background:

  • Kawasaki disease (KD) is a critical pediatric illness affecting coronary arteries (CA).
  • Current KD therapies aim to reduce inflammation and prevent thrombosis but are not universally effective.
  • The unknown molecular pathogenesis of KD hinders the development of novel treatments.

Purpose of the Study:

  • To identify dysregulated gene expression in KD CA.
  • To investigate the role of specific molecules in KD pathogenesis.
  • To provide molecular evidence for persistent inflammation in KD-affected CA.

Main Methods:

  • High-throughput RNA sequencing of KD and control CA.
  • Validation of gene expression using real-time reverse transcription-polymerase chain reaction (RT-PCR).
  • Immunohistochemistry to localize protein expression in tissues.

Main Results:

  • Signalling lymphocyte activation molecule CD84 was significantly upregulated in both acute (16-fold) and chronic (32-fold) KD CA.
  • CD84 was localized to inflammatory cells within KD tissues.
  • Genes related to cellular proliferation, motility, survival, and immune activation (MX2, SP140) were also upregulated in KD CA.

Conclusions:

  • CD84 is markedly upregulated in KD CA, playing a role in immune responses and platelet stabilization.
  • This study provides the first molecular evidence of sustained dysregulated inflammatory responses in CA damaged by KD.
  • Findings suggest CD84 as a potential therapeutic target for Kawasaki disease.

Keywords:
CD84Kawasaki diseasecoronary artery aneurysminflammationvasculitis

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