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Diclofenac-induced pseudoporphyria; an under-recognized condition?

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Summary
This summary is machine-generated.

Pseudoporphyria, a blistering skin condition, can be triggered by medications like diclofenac, even when considered safe. This case highlights the importance of considering drug-induced pseudoporphyria in patients with psoriatic arthritis.

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Area of Science:

  • Dermatology
  • Toxicology

Background:

  • Pseudoporphyria is a photodistributed bullous disorder clinically resembling porphyria cutanea tarda (PCT) but lacking abnormal porphyrin biochemistry.
  • Risk factors include renal failure, dialysis, excessive ultraviolet A exposure, and certain medications, notably nonsteroidal anti-inflammatory drugs (NSAIDs).

Observation:

  • This report details a case of pseudoporphyria induced by diclofenac in a male patient diagnosed with psoriatic arthritis.
  • This represents the second documented instance of diclofenac-associated pseudoporphyria.

Findings:

  • Diclofenac, an NSAID, can precipitate pseudoporphyria, a condition mimicking PCT without biochemical abnormalities.
  • The patient's psoriatic arthritis was being treated with diclofenac when pseudoporphyria developed.

Implications:

  • Diclofenac, previously viewed as a safe NSAID alternative for pseudoporphyria, should be used with caution.
  • This case underscores the need for heightened awareness among dermatologists regarding drug-induced pseudoporphyria, even with commonly prescribed medications.