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Related Experiment Videos

Composite electrode tips containing externally placed drug releasing collars.

G Brewer1, R Mathivanar, M Skalsky

  • 1Telectronics and Cordis Pacing Systems, Sydney, Australia.

Pacing and Clinical Electrophysiology : PACE
|November 1, 1988
PubMed
Summary

New composite electrode tips with steroid-eluting collars effectively reduce stimulation energy. These novel steroid-eluting electrodes eliminate threshold peaking, showing potential for reduced pacing energy requirements in cardiac devices.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cardiology

Background:

  • Conventional pacemaker electrodes can exhibit increased pacing thresholds over time.
  • Steroid elution from electrode surfaces is a strategy to mitigate inflammation and improve chronic performance.
  • A novel composite electrode design integrating a steroid-eluting polymeric collar was investigated.

Purpose of the Study:

  • To evaluate the efficacy of composite electrode tips with dexamethasone sodium phosphate (DSP) eluting collars.
  • To assess the impact of these steroid-eluting electrodes on voltage thresholds and pacing parameters.
  • To compare the performance of novel electrodes against conventional designs in a chronic animal model.

Main Methods:

  • Development of composite electrode tips with integrated DSP-releasing polymeric collars.

Related Experiment Videos

  • Implantation of unipolar ventricular leads in sheep, utilizing both steroid-eluting and control electrodes.
  • Measurement of voltage thresholds, pacing, and sensing impedances over subchronic (less than 6 weeks) and chronic (up to 6 months) periods.

    • Main Results:

    • Steroid-eluting electrodes significantly reduced the acute threshold peaking observed with control leads.
    • A novel mushroom-shaped electrode with a high microsurface Pt/Ir coating maintained stable, low thresholds for up to 6 months.
    • No significant difference in thresholds was noted between implanted and 2-week measurements for steroid-eluting electrodes.

    Conclusions:

    • Composite electrode tips incorporating steroid-releasing collars demonstrate significant potential for reducing stimulation energy.
    • The novel electrode design effectively mitigates the inflammatory response leading to elevated pacing thresholds.
    • These findings suggest a promising approach for improving long-term performance and energy efficiency in cardiac pacing devices.