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[Acute pancreatitis. Neurovascular and microcirculatory changes. Pathogenic and therapeutic study]
J R Salazar1, E Cafferata, G Canavosio
1Cátedra de Cirugía I. Univ. Nac. de Córdoba.
Acta Gastroenterologica Latinoamericana
|January 1, 1987
Summary
The autonomic nervous system minimally impacts acute pancreatitis progression. Nerve blocks and resections reduced pain but not pancreatic damage, though novocaine offered temporary stability.
Area of Science:
- Veterinary Medicine
- Gastroenterology
- Surgical Research
Background:
- Acute pancreatitis is a serious condition with complex pathophysiology.
- The role of the autonomic nervous system in pancreatitis requires further elucidation.
Purpose of the Study:
- To investigate the involvement of the autonomic nervous system in the pathogenesis of acute pancreatitis in dogs.
- To evaluate the effects of interventions targeting the autonomic nervous system on pancreatitis progression.
Main Methods:
- Acute pancreatitis was induced in dogs via bile injection or duodenal loop creation.
- Autonomic nervous system interventions included celiac plexus blocks, splanchnic nerve resections, vagotomy, and novocaine perfusion.
- Pancreatic pathology and animal condition were assessed.
Main Results:
- Celiac plexus blocks and splanchnic nerve resections alleviated pain and shock but did not alter pancreatic pathological changes.
- Vagotomy prior to pancreatitis induction showed no protective effects.
- Continuous intravenous novocaine perfusion managed pain and stabilized the condition during the initial edema phase.
- Enzyme inhibitors (Trasylol) were not effective in the first 24 hours.
Conclusions:
- The autonomic nervous system appears to play a limited role in the progression of established acute pancreatitis.
- Pain and shock management are achievable through autonomic blockade, but this does not prevent pancreatic tissue damage.
- Novocaine shows potential for symptomatic management in the early stages of pancreatitis.