[Acute pancreatitis. Neurovascular and microcirculatory changes. Pathogenic and therapeutic study]

A group of 159 dogs divided in 8 sub-groups were studied, in regard to pancreatitis, the purpose of the study was to investigate the participation of the automatic nervous system in the course of acute pancreatitis. The procedures and the results were as follows: 1. Pancreatitis was induced in two forms: a) Injection of gallbladder bile, from the same animal to the pancreatic duct. b) Blind duodenal loop with exclusion of the distal duodenum through the pylorus. In both cases acute pancreatitis was obtained. Fat necrosis was predominant in type a, and hemorrhagic lesions in type b. 2. The anesthetic block of the celiac plexus controlled the pain and shock. The animals were in good general conditions but there were no changes in the pathological process of the pancreas. The same results were noted in surgical resections of splanchnic trunks. 3. When the surgical resections of splanchnic nerves was followed by a waiting period of 20 days from the production of pancreatitis there were no changes in the gland. 5. Vagotomy previous to pancreatitis does not have protector effects in the induction of pancreatitis. 6. Continuous perfusion of E.V. novocaine was of extreme utility. The animals remained without pain and the process remained stable when it was given in the initial face of edema. 7. The enzyme inhibitor (Trasylol) given in the first 24 hs. does not prove to be valuable. Due to the fermentative derangement the condition of the animals was better maintained in relation to the comparative animals.