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Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?
Teresa Martínez1, Tomás Chivato, Marta Roldán
1aRadiopharmacy Unit, Santa Lucia's Hospital, Cartagena bRadiopharmacy Unit, Virgen de la Arrixaca Hospital, Murcia, Spain.
Abstract:
To avoid adverse effects during the administration of [(123)I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [(123)I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [(123)I] iodide on solid-phase extraction. No increase in percentages of free [(123)I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [(123)I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.
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