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Darkroom prone provocative test in primary angle closure glaucoma relatives.

Mimiwati Zahari1, Yu Ming Ong, Rohana Taharin

  • 1*MSOphth †MRCOphth, MSOphth University Malaya Eye Research Centre, Department of Ophthalmology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia (MZ, YMO, NR); and Department of Ophthalmology, Bukit Mertajam Hospital, Pulau Pinang, Malaysia (RT).

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Summary

Family members of primary angle closure glaucoma patients with shallower anterior chambers and thicker lenses are more likely to have a positive darkroom prone provocative test (DPPT). These ocular biometric risk factors indicate a predisposition to primary angle closure (PAC).

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Ocular Biometry

Background:

  • Primary angle closure glaucoma (PACG) is a significant cause of vision loss.
  • Family members of PACG patients are at increased risk.
  • Ocular biometric parameters are key risk factors for PACG.

Purpose of the Study:

  • To assess ocular biometric parameters in relatives of PACG patients.
  • To evaluate the darkroom prone provocative test (DPPT) response in these family members.
  • To determine correlations between biometric data and DPPT results.

Main Methods:

  • Seventy-four family members of PACG patients were studied.
  • Evaluations included ultrasound ocular biometry, slit lamp biomicroscopy, tonometry, fundus examination, gonioscopy, and DPPT.
  • Statistical analysis was performed to identify correlations.

Main Results:

  • 6 (8.1%) family members had primary angle closure (PAC), and 8 (10.8%) were PAC suspects.
  • Positive or borderline DPPT responses were observed in 66.7% of affected individuals and 87.5% of PAC suspects.
  • Shallow anterior chamber depth, thick lens, short axial length, and anterior lens position were noted in affected and suspect individuals.

Conclusions:

  • Anterior chamber depth and lens thickness significantly correlate with a positive DPPT response.
  • Ocular biometric risk factors for PACG are present in affected and at-risk family members.
  • Longitudinal studies are recommended to validate DPPT for identifying individuals at risk of PAC.