Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Valves01:16

Heart Valves

14.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
14.9K
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

1.1K
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
1.1K
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

3.4K
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
3.4K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

632
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
632
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

753
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
753
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

544
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
544

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mathematical representation and nonlinear modelling of the Wheatley mitral valve.

Medical engineering & physics·2025
Same author

Regularization of a Mathematical Model of the Wheatley Heart Valve.

Journal of biomechanical engineering·2022
Same author

A Mathematical Representation of the Wheatley Heart Valve.

Journal of biomechanical engineering·2021
Same author

The aortic valve: structure, complications and implications for transcatheter aortic valve replacement.

Perfusion·2014
Same author

Cytokines in the systemic inflammatory response syndrome: a review.

HSR proceedings in intensive care & cardiovascular anesthesia·2013
Same author

The impact of different biocompatible coated cardiopulmonary bypass circuits on inflammatory response and oxidative stress.

Perfusion·2010

Related Experiment Video

Updated: May 2, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.7K

Percutaneous heart valves; past, present and future.

M M Rozeik1, D J Wheatley2, T Gourlay2

  • 1Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK monica.rozeik@strath.ac.uk.

Perfusion
|March 19, 2014
PubMed
Summary

Percutaneous heart valves offer hope for high-risk patients, with ongoing development aiming for wider use. Continued design and clinical improvements may soon make these less invasive valves suitable for lower-risk individuals.

Keywords:
futurehistorynext generation valvespercutaneous deliverytranscatheter aortic valve replacement

More Related Videos

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

13.1K
Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
10:56

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

17.9K

Related Experiment Videos

Last Updated: May 2, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.7K
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

13.1K
Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
10:56

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

17.9K

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Interventional Cardiology

Background:

  • Percutaneous heart valves (PHVs) represent a significant advancement for patients with severe valve disease who are unsuitable for traditional surgery.
  • Over 50 PHV designs have emerged since their inception over a decade ago, with notable examples like the CoreValve and Edwards SAPIEN valves undergoing extensive clinical evaluation.
  • The Edwards SAPIEN valve has received FDA approval for inoperable patients, highlighting progress in transcatheter valve technology.

Purpose of the Study:

  • To review the historical development and current status of percutaneous heart valves.
  • To identify key design considerations crucial for advancing PHV technology.
  • To assess the potential for PHVs to become a standard treatment option for a broader patient population.

Main Methods:

  • Literature review of percutaneous heart valve development, clinical trials, and FDA approvals.
  • Analysis of current complications associated with PHV implantation.
  • Discussion of engineering and clinical factors influencing PHV design and application.

Main Results:

  • Significant progress has been made in PHV technology, with specific valves gaining regulatory approval for high-risk patients.
  • Major complications, including vascular bleeding and stroke, currently limit the widespread adoption of PHVs in operable patients.
  • The review highlights the evolution of valve designs and the ongoing need for refinement.

Conclusions:

  • Percutaneous heart valves have demonstrated considerable promise, particularly for inoperable patients.
  • Further advancements in valve design and increased clinical experience are necessary to overcome current limitations.
  • PHV replacement may eventually be a feasible option for lower-risk patients currently undergoing conventional surgery.