Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular development in chick embryos: a possible role for adenosine.

T H Adair1, J P Montani, D M Strick

  • 1Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.

The American Journal of Physiology
|January 1, 1989
PubMed
Summary

Adenosine plays a role in vascular development. Administering adenosine or dipyridamole decreased vascular resistance in chick embryos, while blocking adenosine increased it.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

It is likely that the drinking of cold and room temperature water decreases cardiac workload.

Acta physiologica (Oxford, England)·2014
Same author

Cardiovascular and metabolic responses to tap water ingestion in young humans: does the water temperature matter?

Acta physiologica (Oxford, England)·2014
Same author

HEMODYNAMICS.

A listing of research in the cardiovascular field·2014
Same author

Sitting comfortably versus lying down: is there really a difference in energy expenditure?

Clinical nutrition (Edinburgh, Scotland)·2013
Same author

Electronic counting and size determination of particles in aerosols.

The Journal of industrial hygiene and toxicology·2010
Same author

Physiology of botulinus toxin.

Archives of neurology and psychiatry·2010

Area of Science:

  • Cardiovascular Research
  • Developmental Biology
  • Pharmacology

Background:

  • Vascular development is crucial for embryonic growth.
  • The role of adenosine in regulating vascular growth is not fully understood.

Purpose of the Study:

  • To investigate the potential role of adenosine in the development of the vasculature in chick embryos.

Main Methods:

  • Chick embryos (n=217) were treated with adenosine, inosine, dipyridamole, or aminophylline from days 11-14.
  • Whole body vascular resistance (SVR) was measured on day 15 as an indicator of vascularity.

Main Results:

  • Adenosine and inosine decreased SVR in a dose-dependent manner, by up to 30%.
  • Dipyridamole also dose-dependently decreased SVR by approximately 30%.

Related Experiment Videos

  • Aminophylline administration led to a dose-dependent increase in SVR, up to 100% above controls.

    • Conclusions:

    • Adenosine appears to have a physiological role in regulating vascular system growth in chick embryos.
    • These findings suggest adenosine as a potential target for modulating vascular development.