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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cognitive and physical function in chronic kidney disease.

Daniel E Weiner1, Stephen L Seliger

  • 1aTufts Medical Center, Boston, Massachusetts bUniversity of Maryland Medical Center, Baltimore VA Medical Center, Baltimore, Maryland, USA.

Current Opinion in Nephrology and Hypertension
|March 19, 2014
PubMed
Summary
This summary is machine-generated.

Cognitive and physical impairments are common in chronic kidney disease (CKD). Microvascular disease may be a unifying cause, impacting quality of life and necessitating further research for effective treatments.

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Area of Science:

  • Nephrology
  • Neurology
  • Gerontology

Background:

  • Chronic kidney disease (CKD) frequently co-occurs with cognitive and physical impairments.
  • These impairments significantly reduce quality of life and overall health in CKD patients.
  • Microvascular disease is increasingly recognized as a potential common pathway for these comorbidities.

Purpose of the Study:

  • To review the prevalence and impact of cognitive and physical impairments in CKD.
  • To explore recent research linking microvascular disease to these functional deficits.
  • To summarize current understanding of treatment effects on physical performance.

Main Methods:

  • Systematic review of recent small studies on cognitive and physical function in CKD.
  • Analysis of data on comorbid conditions, particularly microvascular disease.
  • Evaluation of studies on physical activity, frailty, and exercise interventions.

Main Results:

  • CKD patients exhibit a high burden of comorbidities, including microvascular disease, contributing to cognitive impairment.
  • Physical function is significantly diminished in CKD, with reduced activity linked to poorer outcomes.
  • Frailty is prevalent and associated with increased mortality; exercise shows modest short-term benefits.

Conclusions:

  • Cognitive and physical decline are critical issues for individuals with CKD.
  • Further research is essential to develop effective treatments for these intertwined conditions in CKD.
  • Understanding the role of microvascular disease may offer new therapeutic targets.