Related Experiment Videos
High-dose methylprednisolone suppresses experimental allergic neuritis in the Lewis rat
P M Watts1, W A Taylor, R A Hughes
1Department of Neurology, United Medical and Dental Schools, Guy's Hospital, London, United Kingdom.
Experimental Neurology
|January 1, 1989
Abstract:
High dose methylprednisolone (50 mg kg-1, daily) was administered to Lewis rats with experimental allergic neuritis from onset of the disease. Disease severity was reduced and recovery was significantly more rapid than that in saline-injected controls. Histological examination showed reduction of endoneurial edema, cellular infiltration, and demyelination. The results provide experimental evidence supporting the trial of high dose steroids in human demyelinating polyradiculoneuropathy.