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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Epidemiology of bronchopulmonary dysplasia

Erik A Jensen1, Barbara Schmidt

  • 1Division of Neonatology, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|March 19, 2014
PubMed

Insights

Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth, affecting infants with low birth weight. This review covers BPD

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Perinatal Health

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication affecting premature infants.
  • It impacts at least 25% of infants born weighing less than 1500 grams.
  • Incidence correlates with reduced gestational age and lower birth weight.

Purpose of the Study:

  • To review the diagnostic criteria for BPD.
  • To summarize the incidence and risk factors associated with BPD.
  • To discuss the long-term outcomes of BPD in affected infants.

Main Methods:

  • Literature review of existing studies on Bronchopulmonary dysplasia.
  • Synthesis of data on diagnostic standards, prevalence, and contributing factors.
  • Analysis of reported long-term consequences for infants with BPD.

Main Results:

  • BPD is a frequent and severe outcome of preterm birth.
  • Key risk factors include prematurity, low birth weight, intrauterine growth restriction, sepsis, and prolonged mechanical ventilation/oxygen support.
  • Diagnosis of BPD is linked to chronic respiratory issues and developmental delays.

Conclusions:

  • Bronchopulmonary dysplasia presents substantial challenges in neonatal care.
  • Understanding risk factors and diagnostic criteria is crucial for management.
  • Long-term monitoring is essential due to predicted adverse respiratory and neurodevelopmental outcomes.

Keywords:
bronchopulmonary dysplasiachronic lung diseaseepidemiologymechanical ventilationvery low birth weight

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