Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway
1Department of Pharmacology, Moores Cancer Center University of California, San Diego, La Jolla, CA, USA.
Abstract:
The Hippo pathway plays a critical role in organ size control and tumorigenesis. YAP (and also its homologue TAZ) is a transcription co-activator that mediates the biological functions of the Hippo pathway. YAP activity is inhibited upon phosphorylation by the Lats kinases (reviewed in Yu & Guan, 2013). In a recent study in Cell, Mori et al (2014) uncover a new function of YAP in global microRNA (miRNA) biogenesis by the modulation of the Microprocessor machinery. The results also suggest that this novel YAP function may contribute to cell growth control and tumorigenesis.
More Related Videos
Related Concept Videos
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps
Regulation of Expression at Multiple Steps
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...
Pre-mRNA Processing: Modification of pre-mRNA Ends
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
Transcription
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...


