Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy
Majid Teremmahi Ardestani1, Hossein Hadi Nodushan1, Abbas Aflatoonian2
1Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background:
Recurrent pregnancy loss (RPL) caused by various genetic and non-genetic factors. After chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause RPL. Factor V Leiden and factor II G20210A mutation were the most common mutations cause thrombophilia in the world.
Objective:
The purpose of this study was to determine the frequency of factor V Leiden and prothrombine gene mutations in women with RPL compared with women who had uneventful pregnancies.
Materials And Methods:
This case control study evaluates the frequency of factor V-Leiden and factor II G20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. The mutations were assessed by PCR-RFLP.
Results:
Frequency of the factor V Leiden among cases was 2.5%, which was higher than controls (1.25%), but the difference was not significant. No factor II G20210 mutation was found among cases and controls.
Conclusion:
These data did not confirm that factor V Leiden and factor II G20210 mutation might play a role in recurrent pregnancy loss in Iranian women.
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