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Updated: May 2, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Primary small cell undifferentiated (neuroendocrine) carcinoma of the maxillary sinus
Santosh Kumar Yadav1, Premalatha Shetty2
1Department of Oral and Maxillofacial Surgery, Chitwan Medical College (P) Ltd, P.O. Box 42, Bharatpur-10, Chitwan, Nepal.
Abstract:
Primary small cell neuroendocrine carcinoma (SNEC) of the paranasal sinuses is an extremely rare and distinctive tumor with aggressive clinical behavior. Moreover, SNECs originating in the head and neck region have been reported to be highly aggressive and to have a poor prognosis. This report describes a patient with a maxillary sinus SNEC who was successfully treated with neoadjuvant chemotherapy and concurrent chemoradiotherapy.
