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Coronary artery disease. A study of three polymorphic sites of adenosine deaminase gene

Patrizia Saccucci, Agnieszka Binczak-Kuleta, Maria Banci

    Acta Cardiologica
    |March 20, 2014
    PubMed

    Insights

    Genetic variations in the Adenosine Deaminase (ADA) gene are linked to coronary artery disease (CAD) risk in males. Specific ADA gene polymorphisms and haplotypes show significant differences between CAD patients and controls.

    Area of Science:

    • Cardiovascular Genetics
    • Biochemistry

    Background:

    • Adenosine is a known cardioprotective agent.
    • Impaired adenosine signaling contributes to heart failure.
    • Genetic variations in Adenosine Deaminase (ADA) gene are associated with coronary artery disease (CAD).

    Purpose of the Study:

    • Investigate the relevance of three intragenic polymorphic sites (ADA1, ADA2, ADA6) of the ADA gene.
    • Examine the association between ADA gene polymorphisms and CAD.
    • Explore the role of ADA gene in CAD susceptibility and clinical course.

    Main Methods:

    • Studied 136 non-diabetic CAD patients and 246 healthy controls (Italian population).
    • Studied 129 non-diabetic CAD patients and 204 newborns (Polish population).
    • Determined ADA1, ADA2, and ADA6 genotypes using DNA analysis.

    Main Results:

    • In males, lower proportions of ADA1*2 and ADA2*2 alleles were observed in CAD patients compared to controls.
    • Statistically significant differences in haplotype distributions (ADA1-ADA2, ADA1-ADA6, ADA2-ADA6) were found between male CAD patients and controls.

    Conclusions:

    • The ADA gene shows a complex association with coronary artery disease.
    • Beyond adenosine deamination, other ADA gene functions may influence CAD susceptibility and progression.
    Abstract

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