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Related Experiment Video

Updated: May 2, 2026

Milk Collection Methods for Mice and Reeves' Muntjac Deer
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Milk-borne relaxin and reproductive system development.

Carol A Bagnell, Frank F Bartol

    Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia
    |March 20, 2014
    PubMed
    Summary

    Maternal colostrum delivers bioactive factors like relaxin to newborns, supporting early development. This highlights the crucial role of nursing in neonatal programming via milk-borne signals.

    Area of Science:

    • Reproductive biology
    • Neonatal development
    • Endocrinology

    Background:

    • Maternal programming of neonatal development occurs early in life through nursing.
    • Colostrum, or first milk, facilitates the transfer of bioactive factors from mother to offspring.
    • The lactocrine hypothesis proposes that milk-borne factors influence neonatal development.

    Purpose of the Study:

    • To investigate the role of milk-borne bioactive factors in neonatal development.
    • To examine relaxin as a model for understanding lactocrine signals.
    • To explore the transfer of relaxin from mother to neonate via colostrum.

    Main Methods:

    • Analysis of colostrum composition in multiple species.
    • Detection of relaxin in porcine colostrum.

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  • Review of the lactocrine hypothesis and its implications.

    • Main Results:

    • Relaxin is identified as a prototypical milk-borne bioactive factor.
    • Relaxin is detectable in the colostrum of various species, including pigs.
    • This supports the concept of relaxin transfer from mother to neonate.

    Conclusions:

    • Relaxin in colostrum exemplifies milk-borne signals crucial for neonatal development.
    • The study supports the lactocrine hypothesis by demonstrating relaxin's presence and potential role.
    • Relaxin serves as a valuable model for studying developmental signaling via nursing.