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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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[Odontogenic maxillary sinusitis in elderly and old age].

V V Nikitenko, A K Iordanishvili, G A Ryzhak

    Advances in Gerontology = Uspekhi Gerontologii
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    This study details odontogenic maxillary sinusitis in elderly patients, highlighting unique clinical features and causes, especially concerning oroantral communication. Understanding these aspects is crucial for effective geriatric dental and sinus care.

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    Area of Science:

    • Otorhinolaryngology
    • Geriatric Dentistry

    Background:

    • Odontogenic maxillary sinusitis (OMS) presents unique challenges in elderly patients.
    • Age-related physiological changes can alter disease presentation and treatment outcomes.

    Purpose of the Study:

    • To analyze the clinical picture of OMS in elderly and senile patients.
    • To identify specific causes and clinical features of OMS in older individuals.
    • To investigate the role of oroantral communication in OMS among geriatric populations.

    Main Methods:

    • Detailed clinical analysis of elderly and senile patients diagnosed with OMS.
    • Review of etiological factors contributing to OMS in the geriatric population.
    • Assessment of clinical manifestations, including oroantral communication.

    Main Results:

    • Peculiarities in the clinical presentation of OMS were observed in elderly and senile patients.
    • Specific etiological factors contributing to OMS in older age groups were identified.
    • Clinical features, including the presence and impact of oroantral communication, were documented.

    Conclusions:

    • Elderly and senile patients exhibit distinct clinical patterns of odontogenic maxillary sinusitis.
    • Age-specific factors influence the development and manifestation of OMS.
    • Oroantral communication is a significant consideration in managing OMS in older adults.