The μ-opioid receptor: an electrophysiologist's perspective from the sharp end
1School of Physiology and Pharmacology, University of Bristol, Bristol, UK.
Unlabelled:
Morphine, the prototypical opioid analgesic drug, produces its behavioural effects primarily through activation of micro-opioid receptors expressed in neurones of the central and peripheral nervous systems. This perspective provides a historical view of how, over the past 40 years, the use of electrophysiological recording techniques has helped to reveal the molecular mechanisms by which acute and chronic activation of micro-opioid receptors by morphine and other opioid drugs modify neuronal function.
Linked Articles:
This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2.
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