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Baboon syndrome induced by ketoconazole.

Ali Ihsan Gulec1, Esma Uslu, Elife Başkan

  • 1Department of Dermatology, Duzce Medical Faculty , Duzce , Turkey.

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Summary

A patient developed baboon syndrome, a rash on the buttocks and skin folds, after taking oral ketoconazole. This is the first reported case of ketoconazole-induced baboon syndrome.

Keywords:
Baboon syndromeSDRIFEketoconazole

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Drug-induced hypersensitivity reactions can manifest in various cutaneous patterns.
  • Baboon syndrome is a rare maculopapular eruption linked to specific drugs or allergens.

Observation:

  • A 27-year-old male presented with a distinctive rash on flexural areas and buttocks.
  • The eruption appeared after initiating oral ketoconazole therapy.
  • The patient had a history of sensitivity to topical ketoconazole.

Findings:

  • The clinical presentation and histopathology confirmed drug-induced baboon syndrome.
  • Ketoconazole was identified as the causative agent.
  • This represents the first documented instance of ketoconazole-induced baboon syndrome in English literature.

Implications:

  • Highlights the potential for ketoconazole to induce baboon syndrome.
  • Emphasizes the importance of considering drug reactions in patients with characteristic rashes.
  • Suggests a need for increased awareness among clinicians regarding this adverse drug reaction.