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Published on: December 7, 2014
Interferon apha 2b for treating patients with JAK2V617F positive polycythemia vera and essential thrombocytosis
Zhi-Rong Zhang1, Yan-Chao Duan
1Department of Hematology, Affiliated Hospital of Taishan Medical University, Tai'an, China
Objective:
To investigate interferon (IFN) alpha 2 b for treating patients with JAK2V617F positive polycythemia vera (PV) and essential thrombocytosis (ET).
Methods:
Interferon alpha 2 b was used to treat patients with JAK2V617F positive PV and ET. In control group, hydroxyurea was used. Endpoint of study was to compare rates of hematological and molecular remission.
Results:
Patients in the interferon alpha 2 b group achieved higher rates of hematologic and molecular remission than patients in the hydroxyurea group, with a lower incidence of thrombosis.
Conclusion:
Compared with hydroxyurea, interferon alpha 2 b could reduce JAK2V617F load for patients with PV and ET, and achieve higher molecular remission, improve treatment efficacy and reduce complications.
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