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Micro-environmentally restricted cell growth dynamics - modeling considerations.
1a Department of Chemical Engineering, Faculty of Technology and Metallurgy , Belgrade University , Belgrade , Serbia.
Critical Reviews in Biotechnology
|March 20, 2014
Summary
Cellular rearrangement in extracellular matrix, driven by internal stress, restricts cell growth. This process involves migration, deformation, and growth, leading to energy dissipation that impacts cell proliferation.
Area of Science:
- Biophysics
- Cell Biology
- Mathematical Modeling
Background:
- Cellular rearrangement within the extracellular matrix is crucial for tissue development and disease progression.
- Existing models often focus on single time scales, limiting a comprehensive understanding of the phenomenon.
- Micro-environmental restrictions to cell growth are linked to cell cluster dynamics.
Purpose of the Study:
- To connect and discuss various modeling approaches for immobilized cell cluster rearrangement.
- To elucidate the role of internal stress and extracellular matrix rheology in cell growth restriction.
- To analyze cell rearrangement dynamics across different time scales.
Main Methods:
- Review and synthesis of existing literature on cell rearrangement modeling.
- Analysis of models considering short (rearrangement time) and long (growing time) scales.
- Investigation of the interplay between cell migration, deformation, orientation, and growth.
Main Results:
- Cell rearrangement is driven by internal stress, a consequence of matrix rheological response to cell expansion.
- The process involves complex interactions including cell migration, deformation, and changes in cell-cell distances.
- Energy dissipation occurs on both short and long time scales, contributing to growth resistance.
Conclusions:
- Cell rearrangement and associated energy dissipation are key factors in micro-environmental restrictions to cell growth.
- Understanding the anomalous nature of energy dissipation is critical for deciphering biological mechanisms of growth resistance.
- A multi-scale modeling approach is essential for a comprehensive understanding of cell cluster dynamics.
Keywords:
Cell rearrangementextracellular matriximmobilized cell clusterinternal stressmathematical modelingMore Related Videos
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