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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54

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Related Experiment Video

Updated: May 2, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

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Data considerations in ischemic stroke trials.

David S Liebeskind, Edward Feldmann

    Neurological Research
    |March 20, 2014
    PubMed
    Summary

    Future ischemic stroke trials need advanced data collection and analysis expertise. This ensures better understanding of pathophysiology and enables precision stroke care for improved patient outcomes.

    Area of Science:

    • Neurology
    • Clinical Trials
    • Data Science

    Background:

    • Ischemic stroke trial data is crucial for results and future directions.
    • Trial data requirements vary based on the study's purpose, such as novel treatments or clinical practice evaluation.
    • Effective data collection relies on sufficient data, infrastructure, and statistical planning.

    Purpose of the Study:

    • To emphasize the need for enhanced expertise beyond basic considerations in future ischemic stroke trials.
    • To highlight the shift from identifying risk factors to understanding pathophysiology and causation.
    • To advocate for a new approach to data collection for precision stroke care.

    Main Methods:

    • Review of essential data elements and infrastructure for clinical trials.
    Keywords:
    Clinical trials,Data,Outcomes,PrecisionStroke,Treatment,

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    Last Updated: May 2, 2026

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  • Emphasis on expert core lab adjudications complementing local and central data collection.
  • Importance of source data archiving (DICOM imaging, biological specimens) for study interpretation.
  • Utilization of standard terminology, common data elements, and definitions for enhanced study comparison.
  • Role of screening logs in establishing study generalizability.
  • Significance of real-time data transmission and core lab evaluation for adaptive trial design.

    • Main Results:

    • Successful future trials require expertise extending beyond basic data considerations.
    • Efficient data collection and expert core lab adjudications are critical.
    • Archiving source data and utilizing standard terminology improve study interpretation and comparison.
    • Real-time data and core lab evaluations are vital for adaptive trial design.
    • Considering individual pathophysiology and subject characteristics is essential for precision stroke care.

    Conclusions:

    • Future ischemic stroke trials demand a sophisticated approach to data collection and analysis.
    • Integrating individual pathophysiology and subject characteristics is key to advancing precision stroke care.
    • A new paradigm in data collection is necessary to optimize patient outcomes in stroke treatment.