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Updated: May 2, 2026

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster
Published on: September 11, 2013
Aneuploidy and tumorigenesis in Drosophila
Marco Milán1, Marta Clemente-Ruiz2, Andrés Dekanty2
1ICREA, Spain; Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac, 10-12, 08028 Barcelona, Spain.
Abstract:
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the causal relationship between aneuploidy and tumorigenesis remains highly debated. On the one hand, aneuploidy has been shown to be a powerful driver of tumor progression, anticancer drug resistance, and tumor relapse. On the other hand, aneuploidy causes proteotoxic and metabolic stress, which compromises cell cycle proliferation and growth. Here we discuss the role of aneuploidy in tumorigenesis in light of the contribution of Drosophila epithelial cancer models and propose a stress-induced tumor-promoting role of aneuploidy.
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