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Updated: May 2, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?
S Champeris Tsaniras1, N Kanellakis1, I E Symeonidou2
1Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece.
Abstract:
Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer.
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