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Updated: May 2, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Granulomatosis with polyangiitis: recurrence presenting as ependimoplexitis
Cecilia N Pisoni1, Soledad Ibañez, Martín Guevara
1Section of Rheumatology and Immunology, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina. ceciliapisoni@gmail.com.
Abstract:
A 55-year-old man with granulomatosis with polyangiitis (GPA) developed continuous parietal headache, malaise, nasal crusting and dry cough. Neurological exam revealed only left hand hypoesthesia in 4th and 5th finger. Brain MRI showed enlarged right choroid plexus, hyperintense periventricular white matter, thalami and right side of corpus callosum. The suspected diagnosis was ependimoplexitis due to GPA, the patient received three 500 mg methylprednisolone pulses followed by 1 mg/kg of meprednisone with gradual tapering and was switched to oral cyclophosphamide. He had complete resolution of headache. An MRI following this treatment for relapse revealed only minimal ependimal changes.
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