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Updated: May 2, 2026
Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
Published on: September 1, 2011
Prepulse inhibition of the acoustic startle reflex in high functioning autism
Sina Kohl1, Carolin Wolters1, Theo O J Gruendler2
1Department for Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, North Rhine-Westphalia, Germany.
Background:
High functioning autism is an autism spectrum disorder that is characterized by deficits in social interaction and communication as well as repetitive and restrictive behavior while intelligence and general cognitive functioning are preserved. According to the weak central coherence account, individuals with autism tend to process information detail-focused at the expense of global form. This processing bias might be reflected by deficits in sensorimotor gating, a mechanism that prevents overstimulation during the transformation of sensory input into motor action. Prepulse inhibition is an operational measure of sensorimotor gating, which indicates an extensive attenuation of the startle reflex that occurs when a startling pulse is preceded by a weaker stimulus, the prepulse.
Methods:
In the present study, prepulse inhibition of acoustic startle was compared between 17 adults with high functioning autism and 17 sex-, age-, and intelligence-matched controls by means of electromyography.
Results:
Results indicate that participants with high functioning autism exhibited significantly higher startle amplitudes than the control group. However, groups did not differ with regard to PPI or habituation of startle.
Discussion:
These findings challenge the results of two previous studies that reported prepulse inhibition deficits in high-functioning autism and suggest that sensorimotor gating is only impaired in certain subgroups with autism spectrum disorder.
