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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: May 2, 2026

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus
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Viral oncogenesis.

Hung Q Doan1, Marigdalia K Ramírez-Fort, Peter L Rady

  • 1University of Texas Medical Branch, Galveston, Tex., USA.

Current Problems in Dermatology
|March 20, 2014
PubMed
Summary

Human papillomaviruses (HPVs) cause various lesions and are linked to several cancers worldwide. Ongoing research reveals novel oncogenic mechanisms, expanding our understanding of HPV

Area of Science:

  • Virology
  • Oncology
  • Molecular Biology

Background:

  • Human papillomaviruses (HPVs) are epitheliotropic viruses causing benign to malignant lesions.
  • HPVs are implicated in 5.2% of viral-associated cancers globally, including cervical, anogenital, oropharyngeal, and cutaneous malignancies.
  • Over 150 HPV genotypes exist, with a third targeting mucosal sites.

Purpose of the Study:

  • To provide a comprehensive overview of HPV-induced oncogenesis.
  • To highlight key etiological questions for future research in HPV-related cancers.

Main Methods:

  • Review of existing literature on HPV oncogenesis.
  • Analysis of viral oncogene interactions with host cell pathways.
  • Exploration of novel mechanisms like epigenetic modifications and apoptosis modulation.

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Main Results:

  • HPV oncogenesis involves interactions with cell growth and cycle mediators.
  • Emerging mechanisms include epigenetic alterations, apoptosis modulation, and angiogenesis regulation.
  • Current understanding of HPV oncogenesis is evolving with new discoveries.

Conclusions:

  • HPVs play a significant role in various human cancers.
  • Further research is crucial to fully elucidate HPV's etiological role and oncogenic pathways.
  • Future studies will address remaining questions in HPV-associated carcinogenesis.