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Psychotropic drugs block voltage-gated ion channels in neuroblastoma cells
N Ogata1, M Yoshii, T Narahashi
1Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.
Brain Research
|January 2, 1989
Abstract:
Effects of neuroleptics and tricyclic antidepressants on voltage-gated ion channels were investigated in the neuroblastoma cell line N1E-115 using the whole cell variation of patch electrode voltage-clamp techniques. Imipramine, chlorpromazine and haloperidol in micromolar concentrations blocked sodium, calcium and potassium channel currents in a reversible and concentration-dependent manner. The order of potency was chlorpromazine greater than imipramine greater than haloperidol. These direct blocking actions on neuronal ion channels might play a role in clinical effects of these drugs.