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Review: R28 retinal precursor cells: the first 20 years
1University at Buffalo, Center for Hearing and Deafness, SUNY Eye Institute, Buffalo, NY.
Molecular Vision
|March 20, 2014
Summary
The R28 cell line, derived from rat retinal precursors, offers a valuable in vitro model for studying retinal cell behavior, differentiation, and function. Despite limitations, it remains crucial for retinal research, aiding investigations into gene expression and neuronal processes.
Area of Science:
- Ophthalmology
- Neuroscience
- Cell Biology
Background:
- The R28 cell line was established from postnatal rat retinal cultures.
- Immortalization was achieved using the adenovirus 12S E1A gene.
- It has been utilized for two decades in retinal research.
